During a performance by her band Abacus, co-founded with her husband, they were approached the producer of the Bee Gees and she passed on a demo recording. Barry Gibb was so impressed by her vocals he wrote Ain't Nothing Gonna Keep Me From You and secured her a recording contract.

In 1978, Ain't Nothing Gonna Keep Me From You became DeSario's first hit single. The album it was taken from, Pleasure Train hit #43 on the US charts.

Even though the first single from her debut, Pleasure Train, made #43 on the U.S. pop charts, she hadn't really enjoyed the recording experience and wanted a new direction. It was then that she bumped into an old school mate she had as a teen, Harry Wayne Casey (KC) of KC and the Sunshine Band.

Soon after she caught up with an old school friend, Harry Wayne Casey - better know as KC of KC and the Sunshine Band fame.

In 1980 they released the duet - Yes I'm Ready, a cover of the 1965 Barbara Mason song - and ended up with a smash hit. The single hit  # 2 on the Billboard Hot 100 certified gold, and Adult Contemporary #1 for 2 weeks.

It was taken from her second album Moonlight Madness, released in 1979. Follow-up singles Moonlight Madness and a remake of Dancin' In The Streets charted but didn't make Top 40.

By the end of 1980, Yes, I'm Ready, granted herself one-hit wonder status, She went on to record two more albums for Casablanca , Caught, and Relationships, which was shelved when the Casablanca changed direction.

She recorded two contemporary Christian albums for Word records, A Call to us All and Voices in the Wind, which were co-written with and produced by Bill Purse. In 1986 she was nominated for a Grammy in the gospel category for Best Female Performance. She also wrote for and appeared on various artist's albums. During the same period her music was popular in Japan and the Philippines. Teri's music became more introspective and increasingly challenged conservative Christianity. Finally in 1986 she requested that she be released from her contract at Word records.

DeSario also provided vocals on Truth & Light: Music From The X-Files.